Professor Clare Bryant
Professor of Innate Immunity
Email: ceb27@cam.ac.uk
PA Name:
PA Email:
Twitter: @ClareBryant13 and @Inflammedlab
LinkedIn: https://www.linkedin.com/in/clare-bryant-1b6b0a7/
Wikipedia: https://en.wikipedia.org/wiki/Clare_Bryant
Biography
Clare Bryant is Professor of Innate Immunity in the Departments of Medicine and Veterinary Medicine. She graduated in Biochemistry and Physiology in Southampton University before training as a vet at the Royal Veterinary College in London. She was funded by the Wellcome Trust for her PhD (in London) before moving to the William Harvey Research Institute for 4 years as a Wellcome postdoctoral fellow. She then moved to Cambridge as a Wellcome Trust Career Development Fellow where she is now Professor of Innate Immunity. She has been on secondments in Genentech and GSK, has extensive collaborations with many pharmaceutical companies, is on the scientific advisory board of several biotech companies, has a drug discovery project with Apollo Therapeutics and helped found the natural product company Polypharmakos. During the COVID-19 pandemic she founded, and still runs, the Inflammazoom international seminar series. She was elected as a Fellow of the British Pharmacology Society in 2018, Fellow of the American Academy of Microbiology in 2023 and Fellow of the Learned Society of Wales in 2023.
Research Approach:
The Bryant lab studies innate immune cell signalling in response to Pathogen Associated Molecular Pattern Receptor (PRR) activation during bacterial infection using cutting edge multi-disciplinary approaches (collaborating with mathematicians, physicists, physical chemists and structural biologists) to answer fundamental questions about host-pathogen interactions and how to modify them therapeutically. She also applies these innovative approaches to study PRR-induced inflammatory signalling in chronic diseases of humans and animals. In particularly her work using super resolution, single molecule fluorescent and cryo electron tomography imaging approaches to study Toll-like receptor and NOD-like receptor signalling within cells have revealed novel mechanisms in how these receptors signal.
Current projects:
Inflammasome and cell death signalling in infectious and inflammatory diseases
The molecular basis of TLR4 signalling in infectious and inflammatory diseases
Infections in complex physical environments: sinus infections and bronchiectasis
Selected Publication
Google scholar: https://scholar.google.co.uk/citations?user=6YlEJ6YAAAAJ&hl=en
- Pereira, M., Liang, J., Edwards-Hicks, J., Meadows, A.M., Hinz , C., Liggi , S., Hepprich , M., Mudry, K.H., Griffin, J.L., Fraser, I., Sack, M.N., Hess, C., Bryant, C.E. Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting. Cell Reports (2024) 43; 113700, doi:https://doi.org/10.1016/j.celrep.2024.113700
- Barone, D.G., Carnicer-Lombarte, A., Tourlomousis, P., Hamilton, R.S., Prater, M., Rutz, A.L., Dimov, I.B., Malliaras, G.G., Lacour, S.P., Robertson, A.A.B., Franze, K., Fawcett, J.W., Bryant, C.E. (2022) Prevention of the foreign body response to implantable medical devices by inflammasome inhibition. Proc Natl Acad Sci U S A. 119:e2115857119. doi: 10.1073/pnas.2115857119. PMID: 35298334
- Digby, Z., Tourlomousis, P., Rooney, J., Boyle, J.P., Bibo-Verdugo, B., Pickering, R.J., Webster, S.J., Monie, T.P., Hopkins, L.J., Kayagaki, N., Salvesen, G.S., Warming, S., Weinert, L. and Bryant, C.E. (2021) Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections. Cell Reports 36, 109614. Doi:10.1016/j.celrep.2021.109614
- Tourlomousis, P., Wright, J.A., Bittante, A.S., Hopkins, L.J., Webster, S.J., Bryant, O.J., Mastroeni, P., Maskell, D.J., Bryant, C.E. (2020) Modifying bacterial flagellin to evade Nod-like Receptor CARD 4 recognition enhances protective immunity against Salmonella. Nature Microbiology doi.org/10.1038/s41564-020-00801-y (https://rdcu.be/cbpNC)
- Latty SL, Sakai J, Hopkins L, Verstak B, Paramo T, Berglund NA, Cammorota E, Cicuta PC, Gay NJ, Bond PJ, Klenerman D, Bryant CE (2018) Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub ELife pii: e31377. doi: 10.7554/eLife.31377.
- Pereira, M., Tourlomousis, P., Wright, J.A., Monie, T.P., Bryant, CE (2016) CARD9 negatively regulates NLRP3-induced IL-1β production upon Salmonella infection of macrophages. Nature Communications 7:12874. doi: 10.1038/ncomms12874
Research collaborators
David Klenerman https://www.ch.cam.ac.uk/person/dk10012
Pietro Cicuta https://www.phy.cam.ac.uk/directory/cicuta
Yorgo Modis https://www.mrc-lmb.cam.ac.uk/ymodis/index.html
Nick Gay https://www.bioc.cam.ac.uk/research/gay
Internal
Charlotte Summers
Andres Floto
