Ziad Mallat
Professor of Cardiovascular Medicine
Email: zm255@medschl.cam.ac.uk
PA Name: Samantha Bloxam
PA Email: ziadmallatpa@medschl.cam.ac.uk
Twitter: @ZMallat
LinkedIn: Ziad Mallat
Mastodon/other social media: https://www.med.cam.ac.uk/mallat
Biography (200 words): Ziad Mallat received his MD and degree in Cardiovascular Disease from University of Paris VI, and his PhD from University of Paris VII. He was appointed Director of Research at Inserm, France, in 2007, and is the BHF Professor of Cardiovascular Medicine at the University of Cambridge, UK, since 2010. He has published over 250 papers in peer-reviewed journals. Mallat’s work identified prominent roles for specific pathogenic and regulatory immune pathways in atherosclerosis and post-ischaemic remodelling. His basic research activities are complemented by proof-of-concept clinical trials using immune-modulatory therapies in patients with coronary artery disease. Mallat is on the Editorial Board of Circulation Research and JCI Insight, and is co-Editor of Atherosclerosis.
Research Approach: The research approach combines basic science research, pre-clinical experimentation in animals, and translation clinical investigation in patients.
Current projects: We study the immune mechanisms leading to cardiovascular inflammation in the setting of atherosclerosis, post-ischaemic injury (e.g. myocardial infraction) and aortic aneurysm and dissection. We develop novel immuno-modulatory and vaccination-based strategies to promote protective immune responses, with the aim to radically change the management and treatment of these common and serious cardiovascular diseases.
Selected Publications
- Ait Oufella H, Salomon BL, Potteaux S, Robertson AK, Gourdy P, Zoll J, Merval R, Esposito B, Cohen JL, Fisson S, Flavell RA, Hansson GK, Klatzmann D, Tedgui A, Mallat Z. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 2006, 12 :178-180.
- Wang Y, Ait-Oufella H, Herbin O, Bonnin P, Ramkhelawon B, Taleb S, Huang J, Offenstadt G, Combadière C, Rénia L, Johnson JL, Tharaux PL, Tedgui A, Mallat Z. TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. J Clin Invest. 2010 Feb;120(2):422-32. doi: 10.1172/JCI38136.
- Zouggari Y, Ait-Oufella H, Bonnin P, Simon T, Sage AP, Guérin C, Vilar J, Caligiuri G, Tsiantoulas D, Laurans L, Dumeau E, Kotti S, Bruneval P, Charo IF, Binder CJ, Danchin N, Tedgui A, Tedder TF, Silvestre JS, Mallat Z. B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction. Nat Med 2013; 19:1273-80.
- Tsiantoulas D, Eslami M, Obermayer G, Clement M, Smeets D, Mayer FJ, Kiss MG, Enders L, Weißer J, Göderle L, Lambert J, Frommlet F, Mueller A, Hendrikx T, Ozsvar-Kozma M, Porsch F, Willen L, Afonyushkin T, Murphy JE, Fogelstrand P, Donzé O, Pasterkamp G, Hoke M, Kubicek S, Jørgensen HF, Danchin N, Simon T, Scharnagl H, März W, Borén J, Hess H, Mallat Z*, Schneider P*, Binder CJ. APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans.Nature. 2021;597:92-96. *Equal contribution
- Zhao TX, Sriranjan RS, Tuong ZK, Lu Y, Sage AP, Nus M, Hubsch A, Kaloyirou F, Vamvaka E, Helmy J, Kostapanos M, Jalaludeen N, Klatzmann D, Tedgui A, Rudd JHF, Horton SJ, Huntly BJP, Hoole SP, Bond SP, Clatworthy MR, Cheriyan J, Mallat Z. Regulatory T-cell response to low-dose interleukin-2 in ischemic heart disease. NEJM Evidence. 2021;1; DOI:https://doi.org/10.1056/EVIDoa2100009.
Research collaborators/links
https://www.cardiovascular.cam.ac.uk/directory/zmallat
https://www.immunology.cam.ac.uk/Networkdirectory/zm255
https://www.bhf.org.uk/what-we-do/our-research/our-top-professors/professor-ziad-mallat
