Dr Nick Evans

Dr Nicholas Evans

Stroke Association Senior Clinical Lecturer & Honorary Consultant in Stroke Medicine

Twitter: @nr_evans

LinkedIn: www.linkedin.com/in/nicholas-evans-34a22093

Biography

I am a Stroke Association Senior Clinical Lecturer and an Honorary Consultant in Stroke Medicine at Addenbrooke’s Hospital.

My research considers the links between the vulnerable carotid atherosclerotic plaque, the vulnerable brain, and the vulnerable (frail) individual:

Carotid atherosclerosis: Our research uses multimodal imaging to assess atherosclerotic plaque vulnerability and its response to novel treatments.
Effects on the brain: We are investigating the links between inflammation within atherosclerosis and effects on the brain.
Frailty in stroke: Our work evaluates the link between vascular disease and clinical frailty, and how this affects outcomes after stroke.

I completed my medical training at Sidney Sussex College (University of Cambridge) before completing post-graduate training in Stroke Medicine, Geriatric Medicine, and General Internal Medicine across the East of England. I completed my PhD in neurovascular imaging at Gonville and Caius College (University of Cambridge) and continued my postdoctoral research as a Clinical Lecturer in Cambridge before taking up my consultant post. I have completed further postgraduate training at the University of Dundee and Harvard University.

My research has received awards from the British Heart Foundation, Wellcome Trust, British Association of Stroke Physicians, British Atherosclerosis Society, Royal Society of Medicine, and the Royal College of Physicians

Research Approach:

Our research group uses multimodal imaging techniques (computed tomography, positron-emission tomography, and high-resolution magnetic resonance imaging) to evaluate pathophysiological and morphological features of carotid atherosclerosis, including the response to novel and repurposed treatments. We combine these vascular imaging techniques with advanced neuroimaging (CT perfusion, MRI, and PET) to investigate the links between vascular and brain pathology in both acute stroke and chronic cerebrovascular small vessel disease.

Current projects:

Multimodal imaging studies investigating the effect of repurposed drugs on carotid atherosclerosis (SOLVE and MINOTAUR studies).
Investigating the link between vascular inflammation and neuroinflammation using combined vascular and brain PET (DAEDALUS study).
Evaluating the link between frailty, vascular inflammation, and penumbra in acute stroke (CASSIOPEIA study).
Investigating the treatment-modifying effect of frailty on hyperacute stroke reperfusion therapies (thrombolysis and thrombectomy) (FIESTO study).