Royal Papworth Hospital Affiliated PI - Dr Claire Martin

Claire Martin

Consultant Cardiologist and Electrophysiologist, Royal Papworth Hospital

Affiliated Assistant Professor, University of Cambridge

Assistant Director, Research and Development, Royal Papworth Hospital

Email: claire.martin22@nhs.net

PA Name: Vicki Virgo

PA Email: vicki.virgo@nhs.net

Twitter: @CMartinCardio

LinkedIn: www.linkin.com/in/drclairemartin/

Website: clairemartincardiologist.com

Biography

I undertook undergraduate and clinical training at Cambridge University (Gonville and Caius College). I then completed a PhD at the University of Cambridge into mechanisms of arrhythmia in inherited cardiac conditions, funded by a Medical Research Council Training Fellowship, and for this was awarded the British Cardiovascular Society Young Research Workers’ Prize.
 
After specialist training at Royal Papworth Hospital, I undertook research fellowships in electrophysiology investigating mechanisms and treatment strategies for complex arrhythmias at two world-leading cardiac centres: Barts Heart Centre and the Hopital du Haut-Leveque, Bordeaux, through funding from a European Society of Cardiology Training Grant.

I have been a Consultant Cardiologist and Electrophysiologist at Royal Papworth Hospital since 2018.  I am the Research Lead for Cardiac Rhythm Management and Assistant Director for Research and Development at Royal Papworth Hospital, and hold the position of Affiliated Assistant Professor at the University of Cambridge.

Research Approach:

I conduct and manage clinical research in Cardiac Electrophysiology. My research interests are in furthering our understanding of the mechanisms of complex arrhythmias, especially ventricular tachycardia and atrial fibrillation, and using this to develop novel ablation and implantable cardiac device treatments for arrhythmias to improve clinical outcomes. I also have specific interests in the treatment of arrhythmias in congenital heart disease and in patients with pulmonary hypertension.

My research has been supported by the Medical Research Council, the Wellcome Trust, the European Society of Cardiology and the British Heart Foundation, as well as industry partners including Boston Scientific, Biosense Webster, Medtronic, Abbot and Acutus Medical.

Current projects:

1. Use of Pulsed Field Ablation in the treatment of ventricular arrhythmias: PI, Royal Papworth Hospital and University of Cambridge
2. Identifying new therapeutic targets in human ventricular arrhythmia: PI, Royal Papworth Hospital and University of Cambridge
3. Arrhythmias in Pulmonary Hypertension: PI, Royal Papworth Hospital and University of Cambridge
4. Prospective evaluation of open irrigated ablation catheters with high resolution mapping to treat paroxysmal atrial fibrillation (INTERRUPT-AF): UK CI
5. Real world Data collection in subjects treated with the FARAPULSE Pulsed Field Ablation system (FARADISE): UK PI
6. Clinical Evaluation of the StablePoint Catheter and Force-Sensing System for Paroxysmal Atrial Fibrillation (NEWTON-AF): UK PI
7. A prospective randomised comparative trial of subcutaneous implantable cardioverter defibrillator implantation with and without defibrillation testing (PRAETORIAN-DFT): UK SI

Selected Publications

1. Martin CA, Tilz RRR, Anic A, Defaye P,Luik A, Carlo de Asmundis C, Laure Champ-Rigot L, Saverio Iacopino S, Philipp Sommer P, Elizabeth M Albrecht EM, Jonathan D Raybuck JD, Elizabeth Richards E , Nele Cielen N, Sing-Chien Yap S-C; POLAR ICE Investigators. Acute procedural efficacy and safety of a novel cryoballoon for the treatment of paroxysmal atrial fibrillation: Results from the POLAR ICE study. J Cardiovasc Electrophysiol. 2023 doi: 10.1111/jce.15861
2. Reddy SA, Nethercott SL, Teh W, De Bie EM, Pepke-Zaba J, Toshner MR, Martin CA. Prevalence and clinical significance of conduction disease in patients with idiopathic pulmonary arterial hypertension.J Heart Lung Transplant. 2022 Jul;41(7):861-865. doi: 10.1016/j.healun.2022.03.024. Epub 2022 Apr 7
3. Martin CA, Yue A, Martin R, Claridge S, Sawhney V, Maury P, Lowe M, Combes N, Heck P, Begley D, Fynn S, Snowdon R, Seller N, Murray S, Shepherd E, Ezzat V, Gajendragadkar PR, Honarbakhsh S, Takigawa M, Cheniti G, Frontera A, Thompson N, Massouillie G, Kitamura T, Wolf M, Duchateau J, Klotz N, Vlachos K, Bourier F, Lam A, Pambrun T, Denis A, Sacher F, Cochet H, Jais P, Hocini M, Haissaguerre M, Iriart X, Thambo JB, Derval N. Ultra-High-Density Activation Mapping to Aid Isthmus Identification of Atrial Tachycardias in Congenital Heart Disease. JACC Clin Electrophysiol. 2019 Dec;5(12):1459-1472. doi: 10.1016/j.jacep.2019.08.001.
4. Martin CA, Martin R, Maury P, Meyer C, Wong T, Dallet C, Shi R, Gajendragadkar P, Takigawa M, Frontera A, Cheniti G, Thompson N, Kitamura T, Vlachos K, Wolf M, Bourier F, Lam A, Duchâteau J, Massoullié G, Pambrun T, Denis A, Derval N, Dubois R, Hocini M, Haïssaguerre M, Jaïs P, Sacher F. Effect of Activation Wavefront on Electrogram Characteristics During Ventricular Tachycardia Ablation. Circ Arrhythm Electrophysiol. 2019 Jun;12(6):e007293. doi: 10.1161/CIRCEP.119.007293
5. Martin CA, Takigawa M, Martin R, Maury P, Meyer C, Wong T, Shi R, Gajendragadkar P, Frontera A, Cheniti G, Thompson N, Kitamura T, Vlachos K, Wolf M, Bourier F, Lam A, Duchâteau J, Massoullié G, Pambrun T, Denis A, Derval N, Hocini M, Haïssaguerre M, Jaïs J, Sacher F. Use of novel electrogram ‘Lumipoint’ algorithm to detect critical isthmus and abnormal potentials for ablation in ventricular tachycardia. JACC Clin Electrophysiol. 2019 Apr;5(4):470-479. doi: 10.1016/j.jacep.2019.01.016.

Research collaborators/links

• Mark Toshner: Royal Papworth Hospital and University of Cambridge, Cambridge, UK
• Pier Lambiase, Sherry Honarbakhsh, Ross Hunter: Barts Heart Centre, London, UK
• Neil Srinivasan, Essex Cardiothoracic Centre, Basildon, UK
• Frederic Sacher, Hopital du Haut Leveque, Bordeaux, France
• Masateru Takigawa, Tokyo Medical And Dental University, Tokyo, Japan
• Antonio Frontera, Humanitas Research Hospital, Milan, Italy