Royal Papworth Hospital Affiliated PI - Dr Patrick Calvert

Patrick Calvert

Clinical Director of R&D, Royal Papworth Hospital. Cardiology Consultant

Email: patrick.calvert1@nhs.net

PA Name: Michaela Parr

PA Email: Michaela.parr@nhs.et

Biography 

Patrick Calvert is the Clinical Director of Research and Development at Royal Papworth Hospital (RPH) and a consultant cardiologist in coronary and structural intervention.

He graduated from the Universities of Cambridge and Oxford and trained in the Eastern Deanery for general and interventional cardiology. He undertook a PhD at Cambridge University investigating vulnerable coronary plaques. He was awarded the British Cardiovascular Intervention Society Young Investigators Award and the Journal of the American College of Cardiology Young Author Achievement Award (JACC Imaging).

He is the Cardiovascular National Specialty Leads for the NIHR CRN. He is chair of the British Cardiovascular Intervention Society Structural Heart Disease Research Group responsible for developing collaborative structural heart disease research. He has a broad range of research interests but current focuses on clinical outcomes.

As Cardiovascular Lead for the Cambridgeshire and Peterborough Integrated Care System he drafted a 5y plan to improve the cardiovascular health of the region and weave clinical research into the clinical cardiovascular services.

As Clinical Director for R&D, he devised a 5y strategy to realise the research potential of RPHs move to the Biomedical Campus. This includes substantial investment in RPH R&D infrastructure and the appointment of five 50/50 Research Leader posts.  

Research Approach:

Patrick Calvert works collaboratively with other groups in the UK and abroad to undertake a range of studies from randomised controlled trials to observational registries to provide clinical insight into cardiovascular disease, especially novel structural heart disease.

Current projects:

1. PRIMARY trial – Randomised controlled trial comparing transcatheter edge-to-edge repair of mitral valve to surgery (NIH grant)
2. MRI substudy of PRIMARY Trial (BHF Project Grant)
3. PARADIGM trial – Percutaneous device closure of paravalvular leak
4. European Registry of Paravalvular leak closure
5. British Cardiovascular Intervention Society National Registry of transcatheter implantation of mitral valves
6. REVALVE. Global registry of TAVI-in-TAVI
7. A prospective registry of patients with post infarction ventricular septal defect: a scoping study to evaluate the burden of disease and current treatment patterns in the UK
8. A pilot study to understand whether percutaneous closure improves symptom status and quality of life in patients with paravalvular leak

Selected Publications

1. Somatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasculitis and Atherosclerosis.Ćorović A, Wall C, Nus M, Gopalan D, Huang Y, Imaz M, Zulcinski M, Peverelli M, Uryga A, Lambert J, Bressan D, Maughan RT, Pericleous C, Dubash S, Jordan N, Jayne DR, Hoole SP, Calvert PA, Dean AF, Rassl D, Barwick T, Iles M, Frontini M, Hannon G, Manavaki R, Fryer TD, Aloj L, Graves MJ, Gilbert FJ, Dweck MR, Newby DE, Fayad ZA, Reynolds G, Morgan AW, Aboagye EO, Davenport AP, Jørgensen HF, Mallat Z, Bennett MR, Peters JE, Rudd JHF, Mason JC, Tarkin JM.J Am Coll Cardiol. 2023 Jan 31;81(4):336-354. doi: 10.1016/j.jacc.2022.10.034.PMID: 36697134 Free PMC article.
2. Post-infarction ventricular septal defect: percutaneous or surgical management in the UK national registry.Giblett JP, Matetic A, Jenkins D, Ng CY, Venuraju S, MacCarthy T, Vibhishanan J, O'Neill JP, Kirmani BH, Pullan DM, Stables RH, Andrews J, Buttinger N, Kim WC, Kanyal R, Butler MA, Butler R, George S, Khurana A, Crossland DS, Marczak J, Smith WHT, Thomson JDR, Bentham JR, Clapp BR, Buch M, Hayes N, Byrne J, MacCarthy P, Aggarwal SK, Shapiro LM, Turner MS, de Giovanni J, Northridge DB, Hildick-Smith D, Mamas MA, Calvert PA.Eur Heart J. 2022 Dec 21;43(48):5020-5032. doi: 10.1093/eurheartj/ehac511.PMID: 36124729
3. Percutaneous Device Closure of Paravalvular Leak: Combined Experience From the United Kingdom and Ireland.Calvert PA, Northridge DB, Malik IS, Shapiro L, Ludman P, Qureshi SA, Mullen M, Henderson R, Turner M, Been M, Walsh KP, Casserly I, Morrison L, Walker NL, Thomson J, Spence MS, Mahadevan VS, Hoye A, MacCarthy PA, Daniels MJ, Clift P, Davies WR, Adamson PD, Morgan G, Aggarwal SK, Ismail Y, Ormerod JO, Khan HR, Chandran SS, de Giovanni J, Rana BS, Ormerod O, Hildick-Smith D.Circulation. 2016 Sep 27;134(13):934-44. doi: 10.1161/CIRCULATIONAHA.116.022684. Epub 2016 Sep 1.PMID: 27587432 Free PMC article.
4. Percutaneous closure of postinfarction ventricular septal defect: in-hospital outcomes and long-term follow-up of UK experience.Calvert PA, Cockburn J, Wynne D, Ludman P, Rana BS, Northridge D, Mullen MJ, Malik I, Turner M, Khogali S, Veldtman GR, Been M, Butler R, Thomson J, Byrne J, MacCarthy P, Morrison L, Shapiro LM, Bridgewater B, de Giovanni J, Hildick-Smith D.Circulation. 2014 Jun 10;129(23):2395-402. doi: 10.1161/CIRCULATIONAHA.113.005839. Epub 2014 Mar 25.PMID: 24668286
5. 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial. Joshi NV, Vesey AT, Williams MC, Shah AS, Calvert PA, Craighead FH, Yeoh SE, Wallace W, Salter D, Fletcher AM, van Beek EJ, Flapan AD, Uren NG, Behan MW, Cruden NL, Mills NL, Fox KA, Rudd JH, Dweck MR, Newby DE.Lancet. 2014 Feb 22;383(9918):705-13. doi: 10.1016/S0140-6736(13)61754-7. Epub 2013 Nov 11.PMID: 24224999 Free article. Clinical Trial

Research collaborators/links

M Bennett, J Rudd, J Tarkin, D Newby, M Dweck, Giblett JP, Jenkins D, Ng CY, O'Neill JP, Kirmani BH, Pullan DM, Stables RH, Andrews J, Buttinger N, Kim WC, Kanyal R, Butler MA, Butler R, George S, Khurana A, Crossland DS, Marczak J, Smith WHT, Thomson JDR, Bentham JR, Clapp BR, Buch M, Hayes N, Byrne J, MacCarthy P, Aggarwal SK, Shapiro LM, Turner MS, de Giovanni J, Northridge DB, Hildick-Smith D, Mamas MA, Blackman D.