Royal Papworth Hospital Affiliated PI - Dr Stephen Hoole

Stephen Hoole

Consultant Interventional Cardiologist, Affiliated Associate Professor

Email: s.hoole@nhs.net

PA Name: Sarah Barrett

PA Email: sarah.barrett11@nhs.net

Twitter: @hoole_stephen

LinkedIn: linkedin.com/in/Stephen-hoole-27802742

Biography :  Dr Hoole qualified in medicine with distinction from University of Oxford, and subsequently trained in cardiology in London and Cambridge. He was appointed as a consultant interventional cardiologist in September 2011 with NHS-funded research time. He has published over 150 peer reviewed manuscripts and is an affiliated Associate Professor at the University of Cambridge.

He is a specialist adviser to MHRA interventional device program, NICE interventional procedures program and the NIHR HTA program. He is an Expert Adviser for the NICE Centre for Guidelines and has participated in guideline and position paper publications for the ESC, ACC, AHA and NICE.

Dr Hoole has a specialist clinical interest in relieving patients of angina and performing complex coronary intervention and stenting. He specialises in treating refractory angina and leads the regional coronary sinus reducer service. He is also the national interventional lead for the UK balloon pulmonary angioplasty service.

Dr Hoole’s translational catheter lab research interest centres around the assessment of coronary and ventricular physiology to understand and treat microvascular angina and reduce ischaemia reperfusion injury with cardioprotective strategies that include cardiometabolic- and immuno-modulation. He also has interests in endothelin-1, intracoronary imaging, plaque biology and biomarker sampling and pulmonary hypertension.

Research Approach:

We use catheter lab based coronary (pressure wire, IVUS, OCT, blood sampling catheters) and ventricular (conductance catheter) assessment in patients undergoing interventional procedures to provide insights into various disease states and discover novel treatments. We are particularly interested in innovating new diagnostics and therapeutics, including repurposing drugs to treat heart disease. We also have a large portfolio of commercial trials.

Current projects:

RITA-MI2 – Rituximab in STEMI - https://rita-mi2.eu/

PRIZE-substudy – ET-1 in CMD - https://doi.org/10.1016/j.ijcha.2022.100980

BIOPATTERN – trans-coronary biomarker sampling and relationships to plaque stability and microcirculation https://www.jacc.org/doi/10.1016/j.jacbts.2017.07.007

DAPA-ENERGY – 7T MRI metabolic imaging after Dapagliflozin

MILLAR-BPA – RV pressure volume loops during balloon pulmonary angioplasty.

Selected Recent Publications

1. Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention. Abraham GR, Nyimanu D, Kuc RE, Maguire J, Davenport AP, Hoole SP. J Interv Cardiol. 2022:9154048. doi: 10.1155/2022/9154048.
2. Trans-myocardial blood Interleukin-6 levels relate to intracoronary imaging defined features of plaque vulnerability and predict procedure-induced myocardial infarction. Bambrough P, Peverelli M, Brown AJ, Giblett JP, Bennett MR, West NEJ, Hoole SP CRM 2021; 39: 6-11 doi: 10.1016/j.carrev.2021.10.006.
3. Coronary flow variations following PCI affects diastolic non-hyperemic pressure-ratios more than the whole cycle ratios. Aetesam-ur-Rahman M, Zhao TX, Paques K, Oliveira J, Khialani B, Kyranis S, Braganza DM, Clarke SC, Bennett MR, West NEJ, Hoole SP. J Am Heart Assoc. 2022; 11 (9): e023554 doi: 10.1161/JAHA.121.023554.
4. Adenosine induced Coronary Steal is observed in patients presenting with ST-elevation myocardial infarction.  Aetesam-ur-Rahman M, Brown AJ, Jaworski C, Giblett JP, Zhao T, Braganza DM, Clarke SC, Agrawal SK, Bennett MR, West NEJ, Hoole SP J Am Heart Assoc. 2021;10(13):e019899. doi: 10.1161/JAHA.120.019899.
5. Serial right heart catheter assessment between Balloon Pulmonary Angioplasty sessions identify procedural factors that influence response to treatment.  Hug KP, Coghlan JG, Cannon J, Taboada D, Toshner M, Sheares K, Ruggiero A, Screaton N, Jenkins D, Pepke-Zaba JP, Hoole SP J Heart Lung Transplant. 2021;40(10):1223-1234. doi: 10.1016/j.healun.2021.06.011

Research collaborators/links

Prof Martin Bennett

Dr Jason Tarkin

Prof Ziad Mallat

Prof James Rudd

Dr Tian Zhao

Dr Mark Toshner

Prof Anthony Davenport

Prof Paul White