Michael Inouye
Professor of Systems Genomics & Population Health at University of Cambridge Director of Data Sciences
Munz Chair of Cardiovascular Prediction & Prevention at Baker Heart and Diabetes Institute
Turing Fellow
Biography
Mike grew up in the Seattle area before beginning undergraduate study in 1999 at the University of Washington, where he graduated with BSc's in biochemistry and economics. As a 19 year-old, Mike began analyzing data from the Human Genome Project, spending several years doing research in gene finding and protein structure prediction. He continued studying protein structure as a graduate student at UCLA, but returned to genomics in 2005 when he moved to the Wellcome Trust Sanger Institute. While at Sanger, Mike completed his PhD with Prof Leena Peltonen and Prof Gert-Jan van Ommen and was heavily involved in the analytics for the first wave of genome-wide association studies as well as large-scale studies integrating multi-omic data. After a postdoc at the Walter and Eliza Hall Institute, he was recruited to the faculty at the University of Melbourne in 2012 where he built a research program in systems genomics with a focus on clinical and public health applications. In 2017, Mike was recruited to the Baker Institute and the University of Cambridge to set up a lab spanning Australia and the UK that focuses on core areas of systems genomics, including polygenic risk scores, integrated analysis of multi-omics data and development of analytic tools.
Research Approach:
Computational biology
Bioinformatics
Genomics
Machine learning
Biostatistics
Epidemiology
Current projects:
Our lab's research coalesces around the following priority areas:
- To improve early detection, prediction and prevention of common diseases by leveraging genomic information
- To uncover insights into the molecular and cellular underpinnings of disease in order to prioritise therapeutic targets
- To develop open computational tools and resources which are FAIR (Findable, Accessible, Interoperable, Reusable) and which support translational research
Selected Publications
- The gut microbiome is a significant risk factor for future chronic lung disease. Liu Y, Teo SM, Meric G, Tang HHF, Zhu Q, Sanders JG, Vazquez-Baeza Y, Verspoor K, Vartiainen VA, Jousilahti P, Lahti L, Niiranen T, Havulinna AS, Knight R, Salomaa V, Inouye M. Journal of Allergy and Clinical Immunology 2022. (accepted)
- Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases. Ritchie SC, Lambert SA, Arnold M, Teo SM, Lim S, Scepanovic P, Marten J, Zahid S, Chaffin M, Liu Y, Abraham G, Ouwehand WH, Roberts DJ, Watkins NA, Drew B, Calkin AC, Di Angelantonio E, Soranzo N, Burgess S, Chapman M, Kathiresan S, Khera AV, Danesh J, Butterworth AS, Inouye M. Nature Metabolism 2021. https://doi.org/10.1038/s42255-021-00478-5.
- Polygenic risk scores in cardiovascular risk prediction: a cohort study and modelling analyses. Sun L, Pennells L, Kaptoge S, Nelson CP, Ritchie SC, Abraham G, Arnold M, Bell S, Bolton T, Burgess S, Dudbridge F, Sofianopoulou E, Stevens D, Thompson JR, Butterworth AS, Wood A, Danesh J, Samani NJ, Inouye M*, Di Angelantonio E*. PLOS Medicine 2021. doi:https://doi.org/10.1371/journal.pmed.1003498.
- The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation. Lambert SA, Gil L, Jupp S, Ritchie SC, Xu Y, Buniello A, McMahon A, Abraham G, Chapman M, Parkinson H, Danesh J, MacArthur JAL, Inouye M. Nature Genetics 2021. https://doi.org/10.1038/s41588-021-00783-5.
- Airway microbiota dynamics identify a critical window for interplay of pathogenic bacteria and allergy in childhood respiratory disease. Teo SM, Tang HHF, Mok D, Judd LM, Watts SC, Pham K, Holt BJ, Kusel M, Serralha M, Troy N, Bochkov YA, Grindle K, Lemanske RM, Johnston SL, Gern JE, Sly PD, Holt PG, Holt KE*, Inouye M*. Cell Host & Microbe 2018. 24(3):341-352.
Research collaborators/links
Lab website - https://www.inouyelab.org
Cardiovascular Epidemiology Unit website - https://www.phpc.cam.ac.uk/people/ceu-group/ceu-senior-research-staff/michael-inouye/
